So, I'm a college dropout, and for me not having a degree was an issue until I hit the 10-15 years of experience mark and was up for executive positions. Then not only was it not an issue, no one ever asked.
Yeah, I think there's probably a middle management trap in a lot of organizations where they want you to have an MBA for a director of product management role, but for a vp of product or cpo job they're actively recruiting the exact people they want usually based on job experience or prior success.
I think I skipped over that because I got acquired into the middle management role, no resume or job spec required.