On topic: I'm not a biologist so here's my layman's TLDR, please tell me if this is close.
1) You can tell whether a protien has this viral property by looking at its amino acid sequence
2) Looking at this seqence has shown several reasons why proteins don't often go viral
- The relevant region ends up on the interior of the structure
- The relevant structure is not mechanically likely
- Evolution has come up with tons of biological tricks to prevent it
Off-topic: That is some of the grossest academese I've seen in a while, and it makes this passage near unreadable. I'm saving this sentence as an example for students of what not to do:
> The elucidation of this code has enabled the identification of factors that determine the intrinsic aggregation propensity of these molecules
I'd have a hard time coming up with a sentence that feels more inside-out than that.
>"2) Looking at this seqence has shown several reasons why proteins don't often go viral"
Yes, but to clarify a bit: It looks like all proteins have this ability, but not all are just as likely to get into that state for the reasons mentioned. IE, it should be possible to find some way to make amyloids/prions out of any protein in the lab. It just requires figuring out the necessary conditions for that protein.
>"The elucidation of this code has enabled the identification of factors that determine the intrinsic aggregation propensity of these molecules"
Translation: Being able to get the amino acid sequence of proteins and predict what type of structures such a sequence leads to has allowed researchers to also predict which are likely to form aggregates.
1) You can tell whether a protien has this viral property by looking at its amino acid sequence
2) Looking at this seqence has shown several reasons why proteins don't often go viral
Off-topic: That is some of the grossest academese I've seen in a while, and it makes this passage near unreadable. I'm saving this sentence as an example for students of what not to do:> The elucidation of this code has enabled the identification of factors that determine the intrinsic aggregation propensity of these molecules
I'd have a hard time coming up with a sentence that feels more inside-out than that.