Curious about how this aligns with the bioavailability point discussed in the article. Presumably if the gut lining is where the bulk of metabolism occurs then IV sidesteps this and increase the bioavail drug, leading to improved efficacy.
The gut metabolism makes it less available, which is why if you put it in your stomach not much shows up in your nasal lining. If you spray it or inject it directly where it needs to go, no problem.
